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An integrated genetic, genomic and systems approach defines gene networks regulated by the interaction of light and carbon signaling pathways in Arabidopsis
| Indexado |
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| DOI | 10.1186/1752-0509-2-31 | ||||
| Año | 2008 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Conclusion: The global misregulation of gene networks controlled by light and carbon signaling in cli186 indicates that it represents one of the first Arabidopsis mutants isolated that is specifically disrupted in the integration of both carbon and light signals to control the regulation of metabolic, developmental and regulatory genes. The network analysis of misregulated genes suggests that CLI186 acts to integrate light and carbon signaling interactions and is a master regulator connecting the regulation of a host of downstream metabolic and regulatory processes.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Thum, Karen E. | Mujer |
NYU - Estados Unidos
New York University - Estados Unidos |
| 2 | Shin, Michael J. | Hombre |
NYU - Estados Unidos
Messiah Coll - Estados Unidos New York University - Estados Unidos Messiah College - Estados Unidos |
| 3 | GUTIERREZ-ILABACA, RODRIGO ANTONIO | Hombre |
NYU - Estados Unidos
Pontificia Universidad Católica de Chile - Chile New York University - Estados Unidos |
| 4 | Mukherjee, Indrani | Mujer |
NYU - Estados Unidos
New York University - Estados Unidos |
| 5 | Katari, Manpreet Singh | - |
NYU - Estados Unidos
New York University - Estados Unidos |
| 6 | Nero, Damion C. | Hombre |
NYU - Estados Unidos
New York University - Estados Unidos |
| 7 | Shasha, Dennis | Hombre |
NYU - Estados Unidos
Courant Institute of Mathematical Sciences - Estados Unidos New York University - Estados Unidos |
| 8 | Coruzzi, Gloria M. | Mujer |
NYU - Estados Unidos
New York University - Estados Unidos |
| Fuente |
|---|
| National Science Foundation |
| National Institutes of Health |
| U.S. Department of Energy |
| National Institute of General Medical Sciences |
| NIGMS NIH HHS |
| NIH NRSA |
| Agradecimiento |
|---|
| This work was supported by grants from: DOE (DEFG02-92-20071) and NIH (GM32877) to GMC; NIH NRSA (GM63350) to KET; NSF (DBI0445666) to GMC, DES and RAG; and NSF (IIS-0414763, N2010 IOB-0519985, N2010 DBI-0519984 and DBI-04216040) to DES. We would like to thank Dr. Joanne Chory, Salk Institute for the vector containing the hygromycin phosphotransferase gene (HPT2) that was used to create the ASN1::HPT2 construct used to create the transgenic line for the mutant screen. We would like to thank Dan Tranchina (New York University, Department of Biology and Courant Institute of Mathematical Sciences) for his guidance in the 3-way ANOVA analysis carried out in this study. |
