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| DOI | 10.1523/JNEUROSCI.2429-08.2008 | ||||
| Año | 2008 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Schwann cells play pivotal roles in the development and maintenance of the peripheral nervous system. Here, we show that intact sciatic nerve axons of mice contain a small population of ribosomes, which increases by several orders of magnitude when axons are desomatized (severed from their cell bodies). We furthermore demonstrate, using the Wallerian degeneration slow mouse as a model, that Schwann cells transfer polyribosomes to desomatized axons. These data indicate that Schwann cells have the propensity to control axonal protein synthesis by supplying ribosomes on local basis.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | COURT-GOLDSMITH, FELIPE ALFREDO | Hombre |
Pontificia Universidad Católica de Chile - Chile
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| 2 | Hendriks, William T. | Hombre |
Royal Acad Arts & Sci - Países Bajos
Vrije Univ Amsterdam - Países Bajos Netherlands Institute for Neuroscience NIN - KNAW - Países Bajos Vrije Universiteit Amsterdam - Países Bajos Netherlands Institute for Neuroscience - KNAW - Países Bajos |
| 3 | MacGillavry, Harold D. | Hombre |
Vrije Univ Amsterdam - Países Bajos
Vrije Universiteit Amsterdam - Países Bajos |
| 4 | ALVAREZ-MARIN, JAIME | Hombre |
Pontificia Universidad Católica de Chile - Chile
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| 5 | van Minnen, Jan | - |
Vrije Univ Amsterdam - Países Bajos
Univ Calgary - Canadá Vrije Universiteit Amsterdam - Países Bajos University of Calgary - Canadá Hotchkiss Brain Institute - Canadá |
| Agradecimiento |
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| This work was supported by Fondecyt (1980973, 1070377), Chile; J. v. M. and W. T. J. H. were supported by a European Union STREP Grant ( 12702). We thank Joost Verhaagen and Ruben Eggers for help with the Lentivirus experiments; Angelo Quattrini for EM expertise; Monica Perez, Gloria Mendez, Adrian Thomson, Yvonne Gouwenberg, and Jean Kawasoe for technical assistance; and Guus Smit, Naweed Syed, and Lawrence Wrabetz for critical discussion. |