The results from paleopathological analysis on human remains excavated from Puqueldon 1 site (Lemuy Island, Los Lagos Region) are herein presented. The bones were discovered in a multiple burial dig, excavated on the shell mound located at this area. The human remains belong to a minimal number of 22 individuals, from which four are adults ones, two are young of 18 to 20 years old, five are children of 10 to 12 years old, and seven are unweaned babies. Archaeological and bioanthropological evidence are consistent with a posthispanic, indigenous population and a subsistence pattern that merges horticulture and marine resources gathering. The cause of death of the individuals may be related to certain bone indicators that suggest the presence of tuberculosis between the examined population.