The objective of this paper is to identify areas of high social vulnerability in Ciudad Juarez, Chihuahua, in 2010. The methodology consists in the elaboration of an index of social vulnerability through the use of principle characteristics, exploratory analysis of spatial data and the creation of a spatial regression model. Variables were developed based on information from the XIII general population and housing census conducted in 2010 and subdivided according to geostatistical areas (AGEB). The results show the presence of highly vulnerable social groups (high-high) around the central and northwest areas of the city, with sociodemographic variables acting as the main drivers for vulnerability. These findings may serve as a powerful tool for the generation of public policies as it identifies highly vulnerable areas, thus enabling the proper implementation of social programs.