The ozone column depletion over the western side of South America has been previously explained as a, consequence of winds in the area of the depletion, which lead to the compression and thinning of the ozone layer. However, humidity and methane (originated in the Amazon forest and the Pacific Ocean) transported by these winds toward the stratosphere may also have a role in the ozone depletion. Oxidation of methane generates additional humidity, which in turn reacts,with ozone, destroying it. Humidity and methane levels were measured by NASA and HALOE during an ozone depletion event (,January 1998) that occurred along with El Nino. By analyzing these, measurements, we found that, at different; altitudes, changes in the humidity seem to be associated with changes in the ozone such that an increment. of humidity may lead to an ozone depletion. Moreover, we found that during the event, the sum 2CH4+H2O was roughly constant only at attitudes lower than 50 km; the ratio CH4/H2O exhibited an exponential decay with the altitude that may allow assessing the generation mechanism of stratospheric humidity from methane.