This paper presents results on archaeological research conducted at the Cisnes river basin (similar to 44 degrees S), valley which passes through several environments in western Patagonia, from the westernmost limits of the steppe to the Pacific channels. These are assessed in light of a palaeoenvironmental reconstruction spanning from the Late Pleistocene to the Holocene. Results allow interpreting different ways for approaching the environment; these are exposed both spatially and chronologically. Cultural units defined occupied the space discontinuously and ranking it differentially attending to environmental variability. We correlate our data with available archaeological information for Aisen and adjacent areas. Additionally, we discuss cultural continuity and eventual interaction of steppe hunter-gatherers with peoples from the western archipelagic area.