A new laparoscopic technique allows a peritoneal access through a single umbilical port with less abdominal wall trauma and pain we report a 64 years old male with a right colon adenocarcinoma, detected during a routine colonoscopy. The patient was subjected to a right laparoscopic hemicolectomy through a single SILS (R) Multiple Instrument Access Port, that can accommodate up to three instruments introduced through a 3 cm paraumbilical incision. The surgical procedure was uneventful and the patient had a good postoperative evolution. The pathological study of the surgical piece confirmed the presence of an adenocarcinoma with invasion of the submucosa and without lymph node involvement.