The 27 February, 2010 Maule earthquake (Mw = 8.8) ruptured similar to 400 km of the Nazca-South America plate boundary and caused hundreds of fatalities and billions of dollars in material losses. Here we present constraints on the fore-arc structure and subduction zone of the rupture area derived from seismic refraction and wide-angle data. The results show a wedge shaped body similar to 40 km wide with typical sedimentary velocities interpreted as a frontal accretionary prism (FAP). Landward of the imaged FAP, the velocity model shows an abrupt velocity-contrast, suggesting a lithological change which is interpreted as the contact between the FAP and the paleo accretionary prism (backstop). The backstop location is coincident with the seaward limit of the aftershocks, defining the updip limit of the co-seismic rupture and seismogenic zone. Furthermore, the seaward limit of the aftershocks coincides with the location of the shelf break in the entire earthquake rupture area (33 degrees S-38.5 degrees S), which is interpreted as the location of the backstop along the margin. Published seismic profiles at the northern and southern limit of the rupture area also show the presence of a strong horizontal velocity gradient seismic backstop at a distance of similar to 30 km from the deformation front. The seismic wide-angle reflections from the top of the subducting oceanic crust constrain the location of the plate boundary offshore, dipping at similar to 10 degrees. The projection of the epicenter of the Maule earthquake onto our derived interplate boundary yielded a hypocenter around 20 km depth, this implies that this earthquake nucleated somewhere in the middle of the seismogenic zone, neither at its updip nor at its downdip limit. (c) 2011 Elsevier B.V. All rights reserved.