In this paper we present the results of the analysis carried out with the materials from Gruta de El Manzano archaeological site, located beside Grande River, in Malargue, southern Mendoza province. Using the new information, we discuss the site function, changes trough time, and remark his importance for the northern Patagonia discussion. The last radiocarbon data place the beginning of the occupation in more than 8,000 years BP and confirm the existence of the mid Holocene regional hiatus. The analiced materials shows important changes in their tendencies, especially during the second half of the late Holocene, were different lines of evidencies suggest changes in relation to the mobility, the use of animal and plant resources and the incorporation of pottery technology.