Dataciencia

Colección SciELO Chile

Abenquines A-D: aminoquinone derivatives produced by Streptomyces sp strain DB634

Indexado

WoS	WOS:000298634600002
Scopus	SCOPUS_ID:84255188710

DOI

10.1038/JA.2011.87

Año

2011

Tipo

artículo de investigación

Citas Totales

Autores Afiliación Chile

Instituciones Chile

% Participación
Internacional

Autores
Afiliación Extranjera

Instituciones
Extranjeras

Abstract

New bioactive secondary metabolites, called abenquines, were found in the fermentation broth of Streptomyces sp. strain DB634, which was isolated from the soils of the Chilean highland of the Atacama Desert. They are composed of an amino acid linked to an N-acetyl-aminobenzoquinone. Isolation of the abenquines (1-4), their structure elucidation by NMR analysis and MS, as well as the kinetics of their production are presented. The abenquines show inhibitory activity against bacteria, dermatophytic fungi and phosphodiesterase type 4b. The amino acid attached to the quinone is relevant to the enzyme inhibitory activity. The Journal of Antibiotics (2011) 64, 763-768; doi:10.1038/ja.2011.87; published online 28 September 2011

Revista

Revista	ISSN
Journal Of Antibiotics	0021-8820

Métricas Externas

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Disciplinas de Investigación

WOS
Biotechnology & Applied Microbiology
Immunology
Pharmacology & Pharmacy
Microbiology

Scopus
Pharmacology
Drug Discovery

SciELO
Sin Disciplinas

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Publicaciones WoS (Ediciones: ISSHP, ISTP, AHCI, SSCI, SCI), Scopus, SciELO Chile.

Colaboración Institucional

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Autores - Afiliación

Ord.	Autor	Género	Institución - País
1	Schulz, Dirk	Hombre	IFM GEOMAR - Alemania GEOMAR - Helmholtz-Zentrum für Ozeanforschung Kiel - Alemania
2	Beese, Pascal	Hombre	IFM GEOMAR - Alemania GEOMAR - Helmholtz-Zentrum für Ozeanforschung Kiel - Alemania
3	Ohlendorf, Birgit	Mujer	IFM GEOMAR - Alemania GEOMAR - Helmholtz-Zentrum für Ozeanforschung Kiel - Alemania
4	Erhard, Arlette	Mujer	IFM GEOMAR - Alemania GEOMAR - Helmholtz-Zentrum für Ozeanforschung Kiel - Alemania
5	Zinecker, Heidi	Mujer	IFM GEOMAR - Alemania GEOMAR - Helmholtz-Zentrum für Ozeanforschung Kiel - Alemania Universität Bonn - Alemania
6	DORADOR-ORTIZ, CRISTINA INES	Mujer	Universidad de Antofagasta - Chile
7	Imhoff, Johannes F.	Hombre	IFM GEOMAR - Alemania GEOMAR - Helmholtz-Zentrum für Ozeanforschung Kiel - Alemania

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Origen de Citas Identificadas

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Citas identificadas: Las citas provienen de documentos incluidos en la base de datos de DATACIENCIA

Citas Identificadas: 21.15 %
Citas No-identificadas: 78.85 %

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Citas identificadas: Las citas provienen de documentos incluidos en la base de datos de DATACIENCIA

Citas Identificadas: 21.15 %
Citas No-identificadas: 78.85 %

Financiamiento

Fuente
Ministry of Science
European Commission
European Union (EFRE)
Ministry of Science, Economic Affaires and Transport of the State of Schleswig-Holstein (Germany)
Economic Affaires and Transport of the State of Schleswig-Holstein
Kieler Wirkstoff-Zentrum
EFRE

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Agradecimientos

Agradecimiento
We gratefully thank R Schmaljohann for microscopy, G Kohlmeyer-Yilmaz, M Hoftmann, as well as Dr F Sonnichsen for running and processing NMR experiments. This study is from the Kieler Wirkstoff-Zentrum, which is supported by the Ministry of Science, Economic Affaires and Transport of the State of Schleswig-Holstein (Germany), in the frame of the 'Future Program for Economy', which is co-financed by the European Union (EFRE).
We gratefully thank R Schmaljohann for microscopy, G Kohlmeyer-Yilmaz, M Höftmann, as well as Dr F Sönnichsen for running and processing NMR experiments. This study is from the Kieler Wirkstoff-Zentrum, which is supported by the Ministry of Science, Economic Affaires and Transport of the State of Schleswig-Holstein (Germany), in the frame of the ‘Future Program for Economy’, which is co-financed by the European Union (EFRE).

Agradecimiento

We gratefully thank R Schmaljohann for microscopy, G Kohlmeyer-Yilmaz, M Hoftmann, as well as Dr F Sonnichsen for running and processing NMR experiments. This study is from the Kieler Wirkstoff-Zentrum, which is supported by the Ministry of Science, Economic Affaires and Transport of the State of Schleswig-Holstein (Germany), in the frame of the 'Future Program for Economy', which is co-financed by the European Union (EFRE).

We gratefully thank R Schmaljohann for microscopy, G Kohlmeyer-Yilmaz, M Höftmann, as well as Dr F Sönnichsen for running and processing NMR experiments. This study is from the Kieler Wirkstoff-Zentrum, which is supported by the Ministry of Science, Economic Affaires and Transport of the State of Schleswig-Holstein (Germany), in the frame of the ‘Future Program for Economy’, which is co-financed by the European Union (EFRE).