Muestra métricas de impacto externas asociadas a la publicación. Para mayor detalle:
Departamento Gestión de Conocimiento, Monitoreo y Prospección
Consultas o comentarios: productividad@anid.cl
Consultas o comentarios: productividad@anid.cl
Atacamycins A-C, 22-membered antitumor macrolactones produced by Streptomyces sp C38
| Indexado |
|
||||
| DOI | 10.1038/JA.2011.96 | ||||
| Año | 2011 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Three new 22-membered macrolactone antibiotics, atacamycins A-C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells. The Journal of Antibiotics (2011) 64, 775-780; doi: 10.1038/ja.2011.96; published online 19 October 2011
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Nachtigall, Jonny | Hombre |
TECH UNIV BERLIN - Alemania
Technical University of Berlin - Alemania Technische Universität Berlin - Alemania |
| 2 | Kulik, Andreas | Hombre |
UNIV TUBINGEN - Alemania
Universität Tübingen - Alemania Eberhard Karls Universität Tübingen - Alemania |
| 3 | Helaly, Soleiman | - |
TECH UNIV BERLIN - Alemania
Technical University of Berlin - Alemania Technische Universität Berlin - Alemania |
| 4 | Bull, Alan T. | Hombre |
Univ Kent - Reino Unido
University of Kent - Reino Unido |
| 5 | Goodfellow, Michael | Hombre |
Newcastle Univ - Reino Unido
Newcastle University, United Kingdom - Reino Unido Newcastle University - Reino Unido |
| 6 | ASENJO-DE LEUZE, JUAN ALFONSO | Hombre |
Universidad de Chile - Chile
|
| 7 | Maier, Armin | Hombre |
Oncotest GmbH - Alemania
Charles River Laboratories, Inc. - Estados Unidos |
| 8 | Wiese, Jutta | Mujer |
Leibniz Inst Meereswissensch - Alemania
GEOMAR - Helmholtz-Zentrum für Ozeanforschung Kiel - Alemania |
| 9 | Imhoff, Johannes F. | Hombre |
Leibniz Inst Meereswissensch - Alemania
GEOMAR - Helmholtz-Zentrum für Ozeanforschung Kiel - Alemania |
| 10 | Suessmuth, Roderich D. | Hombre |
TECH UNIV BERLIN - Alemania
Technical University of Berlin - Alemania Technische Universität Berlin - Alemania |
| 11 | Fiedler, Hans-Peter | Hombre |
UNIV TUBINGEN - Alemania
Universität Tübingen - Alemania Eberhard Karls Universität Tübingen - Alemania |
| Fuente |
|---|
| Ministry of Science |
| European Commission |
| European Regional Development Fund |
| Deutsche Forschungsgemeinschaft |
| Royal Society |
| Leverhulme Trust |
| Technische Universität Berlin |
| Economic Affaires and Transport of the State of Schleswig-Holstein |
| EFRE |
| Cluster of Excellence 'Unifying Concepts in Catalysis' |
| Economic Affaires and Transport of the State of Schleswig-Holstein |
| Technische Universität Berlin |
| Kieler Wirkstoff–Zentrum |
| EFRE |
| Agradecimiento |
|---|
| ATB thanks The Leverhulme Trust for an Emeritus Fellowship, and ATB and JAA the Royal Society for an International Joint Project Grant (JP100654). This research was supported by grants from the Deutsche Forschungsgemeinschaft and the Cluster of Excellence 'Unifying Concepts in Catalysis' coordinated by the Technische Universitat Berlin. JFI and JW are grateful to A Erhard for performing the activity tests as well as the Ministry of Science, Economic |
| ATB thanks The Leverhulme Trust for an Emeritus Fellowship, and ATB and JAA the Royal Society for an International Joint Project Grant (JP100654). This research was supported by grants from the Deutsche Forschungsgemeinschaft and the Cluster of Excellence ‘Unifying Concepts in Catalysis’ coordinated by the Technische Universität Berlin. JFI and JW are grateful to A Erhard for performing the activity tests as well as the Ministry of Science, Economic Affaires and Transport of the State of Schleswig-Holstein (Germany) for supporting the Kieler Wirkstoff–Zentrum in the frame of the ‘Future Program for Economy’, which is co-financed by the European Union (EFRE). |
