The archaeology of the Archaic Period in Bolivia has primarily been studied in the central and southern highlands. However, new studies in diverse areas of the valleys and lowlands have demonstrated the existence of important Archaic populations previously unknown. In this paper we present the results obtained through a regional survey in the region of San Lucas, southern Bolivia. We explore the characteristics of the settlement patterns, the technology based on an analysis of lithic assemblages, and we outline a preliminary chronology for the Archaic occupations in this region.