The homeopathy has been practiced for many years, mainly using rodent as a research model. Zebrafish have been used as an animal model in different scientific areas and may represent an important model in studies with this therapy. This paper aimed to evaluate the action of Homeopatila 100 (R) on the growth, the action on the liver and reproduction of zebrafish. The study was carried out with 192 six months old animals. The experimental period was three months, being evaluated the growth, the hepatosomatic and viscerosomatic indexes, the number of hepatocytes per area and the percentage of glycogen in these cells, performing the hepatic histology of males and females. It was evaluated the reproduction of the animals, checking the production and probability of hatching of the eggs. It was found that homeopathy increases the number of hepatocytes and glycogen in females, as well as improved the reproductive indices evaluated.