This article has two objectives: first, to perform a critical review about the quality of life at work in the framework of corporate social responsibility and also analyze its relationship and influence on business results; second, to contrast the above proposals to provide empirical evidence on the matter, based on a sample from a complete panel of observations. The contrast will be made using Chilean companies and two databases: the database of the Chilean Safety Association and the Uniform Codified Statistics for Corporations for the period 2003-2006. Applying data panel techniques, findings show a significant positive relationship between the quality of life at work and business performance, and also that the quality of life at work has a positive impact on business results achieved by corporations.