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NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
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| DOI | 10.4067/S0717-97072012000200013 | ||||||
| Año | 2012 | ||||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
The hydrazide-hydrazone 3 reacted with benzenediazonium chloride to give the phenylhydrazone derivative 5. The latter underwent a series of heterocyclization reactions to give pyridazine, 1,2,3-triazole and pyrazole derivatives. The antitumor evaluation of the newly synthesized products against the three cancer cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCl-H460) and CNS cancer (SF-268) showed that some of them have higher inhibitory effects towards the three cell lines compared to the standard.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| SAMIR, EMAN MOHAMED | Mujer |
National Organization for Drug Control & Research - Egipto
Natl Org Drug Control & Res NODCAR - Egipto National Organization for Drug Control and Research Egypt - Egipto |
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| 1 | Wardakhan, Wagnat W. | - |
Natl Org Drug Control & Res NODCAR - Egipto
National Organization for Drug Control & Research - Egipto National Organization for Drug Control and Research Egypt - Egipto |
| 2 | Samir, Ewan Mohamed | Hombre |
Natl Org Drug Control & Res NODCAR - Egipto
National Organization for Drug Control & Research - Egipto |
